2016 · Q12
Dengue virus is known to cause low platelet count in blood of patient by :
- 1interfering in the process of platelet production in bone marrow
- 2infecting endothelial cells
- 3binding with platelets
- 4accumulating platelets in intestine
Select the correct answer using the code given below :
General KnowledgeBiology
- A1 and 2 only
- B1 and 3 only
- C3 and 4
- D1, 2 and 3
Explanation
Dengue virus lowers the platelet count by several established mechanisms: it suppresses platelet production by infecting bone-marrow progenitor cells (1), it infects endothelial cells causing vascular dysfunction and platelet consumption (2), and dengue-induced antibodies and the virus itself bind platelets, accelerating their destruction (3). There is no recognised mechanism by which dengue accumulates platelets in the intestine, so statement 4 is false. Statements 1, 2 and 3 are correct, giving option (D).